Zacherle is a surname. Notable people with the surname include:
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Franz Zacherle, Austrian sculptor, born in Hall in Tirol, died around 1790
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Thomas Zacherle, Austrian abbot of the monastery of Fiecht
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Bonnie Dale Zacherle, American illustrator and designer
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John Zacherle (1918–2016), American television personality
John Zacherle is the uncle of Bonnie Dale Zacherle.
