Trypanosome may refer to:
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Trypanosomatida, a biological order within Kinetoplastida
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Trypanosoma, a genus within Trypanosomatida whose members are often referred to as trypanosomes
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Trypanosoma brucei, a major human pathogen that causes sleeping sickness
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Trypanosoma cruzi, a major human pathogen that causes Chagas disease
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A morphological class of trypanosomatid with a flagellum laterally attached to the cell body
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