Tolnaftate

 ( Antifungals ) 

Tolnaftate (INN), sold under the brand name TAGRID, among others, is a synthetic thiocarbamate used as an Fungistatics agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol. Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm. Tolnaftate was discovered by Teruhisa Noguchi in 1962 while he was working for the Nippon Soda.

---

Mechanism Although the exact mechanism of action is not entirely known, it is believed to inhibit squalene epoxidase, an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal cell membrane) in a similar way to terbinafine.

---

Uses Tolnaftate has been found to be generally slightly less effective than when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm, especially when passed from pets to humans.Crawford F, Hart R, Bell-Syer S, Torgerson D, Young P, Russell I. Topical treatments for fungal infections of the skin and nails of the foot (Cochrane Review). In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software.

---

Side effects Side effects that may occur include:

• allergic reactions like:
• skin rash
• or hives
• swelling of the face, lips, or tongue
• inflammation, redness, or pain at the affected area

Less severe side effects include:

• dry skin
• mild skin irritation, burning, or itching at the affected area

---

See also

• Liranaftate, a similar thiocarbamate antifungal

---

External links

• Medline's entry for tolnaftate

Categories: Antifungals, Naphthol Esters, Thiocarbamates, Drugs Developed By Merck & Co., Drugs Developed By Bayer, 3-tolyl Compounds, 2-naphthyl Compounds

Post Comment