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trans-4-Hydroxycrotonic acid ( T-HCA), also known as γ-hydroxycrotonic acid ( GHC), is an drug used in scientific research to study the GHB receptor. It is an analogue of γ-hydroxybutyric acid (GHB), as well as an active metabolite of GHB. (2012). 9781609133450, Lippincott Williams & Wilkins. ISBN 9781609133450 Similarly to GHB, T-HCA has been found to be endogenous to the rat central nervous system, and as a metabolite of GHB, is almost certain to be endogenous to humans as well. T-HCA binds to the high-affinity GHB receptor with 4-fold greater affinity than GHB itself, where it acts as an agonist, (2009). 9780123739612, Academic Press. ISBN 9780123739612 but does not bind to the low-affinity GHB binding site, the GABAB receptor. Because of this, T-HCA does not produce sedation.
T-HCA has been shown to cause receptor activation-evoked increases in extracellular glutamate concentrations, notably in the hippocampus.
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