Sisulu is a surname. Notable people with this surname include:
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Albertina Sisulu (1918–2011), anti–apartheid activist
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Beryl Rose Sisulu (born 1948), South African diplomat and lawyer, South African Ambassador to Mexico
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Lindiwe Sisulu (born 1954), South African Minister of Defence and Military Veterans
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Max Sisulu (born 1945), Speaker of the National Assembly of South Africa
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Mlungisi Sisulu (1948–2015), South African businessman
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Samuel Sisulu (1956–2003), South African anti-apartheid activist, Soweto uprising student leader and founder of South African Freedom Organisation (SAFO)
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Shaka Sisulu, South African social and political activist, entrepreneur and media personality.
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Walter Sisulu (1912–2003), Secretary-General of the African National Congress
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Zwelakhe Sisulu (1950–2012), South African journalist, editor, newspaper founder, CEO of SABC, and businessperson
Fictional characters
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Thandi Sisulu, a fictional character in the Madam & Eve comic strip
