Propyphenazone

 ( Analgesics ) 

Propyphenazone (known as isopropylantipyrine in Japan) is a derivative of phenazone with similar analgesic and antipyretic effects. Originally patented in 1931,

propyphenazone is marketed as a combination drug with paracetamol and caffeine for treatment of primary headache disorder.

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Serious adverse events Case reports have described acute inferior-wall myocardial infarctions characterized by low atrial rhythms (Kounis syndrome) secondary to propyphenazone use.

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Excerpt from WHO comments

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Banned Propyphenazone is banned in some countries including Sri Lanka, Malaysia, and Thailand.

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Synthesis

Ethyl 2-isopropylacetoacetate (1) and phenylhydrazine (2) are combined to form the pyrazolone ring in the intermediate (3), which is alkylated with methyl iodide to yield propyphenazone.

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See also

• Propyphenazone/paracetamol/caffeine

Categories: Analgesics, Antipyretics, Pyrazolones, Isopropyl Compounds

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