Pivenfrine (), also known as pivalylphenylephrine or phenylephrine pivalate, is a sympathomimetic and mydriatic drug which was never marketed. It is the 3-pivalate ester of phenylephrine. Pivenfrine has much greater lipophilicity than phenylephrine. Higher lipophilicity is known to greatly improve permeability, as in dipivefrine (epinephrine dipivalate). Another related compound is etilefrine pivalate (ethylnorphenylephrine pivalate).
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