Phenuiviridae is a family of negative-strand RNA viruses in the order Hareavirales. , , humans, and mosquitoes serve as natural hosts.
Virology
Structure
Members of
Phenuiviridae are Viral envelope viruses with helical
capsid morphology. Envelope
of these viruses are distributed with icosahedral symmetry (T=12).
Genome
Phenuiviridae is a negative-sense single-stranded RNA virus family.
Its genome is segmented into three pieces: L segment (encoding RNA-dependent RNA polymerase), M segment, and S segment.
Some members of the family have ambisense gene encoding on the S segment (Capsid). The M segment includes envelope glycoproteins encoded in a polyprotein that is cleaved by host . Multiple different proteins can be encoded on the M segment due to leaky scanning by the ribosome.
Life cycle
RNA transcripts are
Five-prime cap through
cap snatching, but not
Polyadenylation.
Translation is terminated by a
Hairpin ribozyme at the end of each RNA transcript.
Taxonomy
The family contains the following genera:
See also