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Large-tooth flounders or sand flounders are a family, Paralichthyidae, of .Kells, V.; and Carpenter, K. (2011). A Field Guide to Coastal Fishes from Maine to Texas. The family contains 14 genera with a total of about 110 species. They lie on the sea bed on their right side; both eyes are always on the left side of the head, while the Pleuronectidae usually (but not always) have their eyes on the right side of the head.
They are found in temperate and tropical waters of the Atlantic, Indian Ocean and . "Paralichthyidae" World Register of Marine Species. Retrieved 2014-1-26.
Several species are important commercial and , notably the California halibut, Paralichthys californicus and the Pacific sanddab, Citharichthys sordidus.
Phylogenetic analyses have long indicated the non-monophyly of this family e.g., and two lineages have been consistently apparent. Termed groups, the two groups were named after genera: a Cyclopsetta group and a Pseudorhombus group (see summary in ). A formal description of Cyclopsettidae in 2019 created this family consisting of four genera: Cyclopsetta, Etropus, Citharichthys, and Syacium corresponding to the previously recognized Cyclopsetta group. Molecular phylogenetic evidence indicates that Paralichthyidae in this sense is sister to Pleuronectidae and Cyclopsettidae is sister to Bothidae e.g.
The earliest known fossil remains of the Paralichthyidae are Priabonian-aged fossil Otolith assigned to Citharichthys altissimus from Louisiana, USA. One extinct fossil genus is known in Evesthes from the Late Miocene of California, USA.
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