Paladini is a surname. Notable people with the surname include:
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Arcangela Paladini (1599–1622), Italian painter, singer and poet
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Daniel Paladini (born 1984), American soccer player
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George dos Santos Paladini (born 1978), Brazilian soccer player
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Giacomo Paladini (d. 1470), Italian Roman Catholic bishop
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Gianni Paladini (born 1945), Italian football club chairman
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Giovanni Domenico Paladini (1721-1772), Italian painter
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Riccardo Paladini (1879–1943), Italian admiral
