Mometasone, also known as mometasone furoate, is a steroid (specifically, a glucocorticoid) medication used to treat certain , hay fever, and asthma.[ It can be applied to the skin, inhaled, or used in the nose.][ Mometasone furoate, not mometasone, is used in medical products.]
Common side effects when used for asthma include headache, sore throat, and Candidiasis.[ It is therefore recommended to rinse the mouth after use.][ Long-term use may increase the risk for glaucoma and cataracts.][ Common side effects when used in the nose include upper respiratory tract infections and nose bleeds.][ Common side effects when applied on the skin include acne, skin atrophy, and itchiness.][ It works by decreasing inflammation.][
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Mometasone furoate was patented in 1981 and came into medical use in 1987.
Medical uses
Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema
Some low-quality evidence suggests the use of mometasone for symptomatic improvement in children with adenoid hypertrophy.
Mometasone is used to alleviate inflammation and itchiness in skin conditions that respond to treatment with glucocorticoids such as psoriasis and atopic dermatitis.
Nasal Mometasone is used in people over two years of age to diminish the symptoms of hay fever (seasonal allergic rhinitis) and other allergies (perennial rhinitis), including nasal congestion, discharge, pruritus, sneezing, and treat nasal polyps.
It is not useful for the common cold.
Asthma
Mometasone furoate can be used with formoterol for the treatment of asthma, due to its anti-inflammatory properties.
Contraindications
People should not use inhaled mometasone or mometasone nasal spray if they have:
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glaucoma or cataracts
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hypersensitivity, or are allergic to any ingredient in mometasone
Those who are using mometasone nasal or inhaled for a long period of time (e.g. more than three months) should get regular eye exams to check for glaucoma and and should take precautions to avoid infections such as taking a vitamin D supplement, staying away from those with an infection (chickenpox, measles, colds or flu, COVID-19), washing foods, hand washing and calling a family doctor at the first sign of a severe infection.
People should not use mometasone topical (skin cream) if:
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hypersensitive or allergic to any ingredient in the skin cream
The risks of Mometasone furoate to the baby during pregnancy cannot be ruled out.
Side effects
The nasal spray form of mometasone may cause the following :
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headache
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Virus upper respiratory infections
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sore throat
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nose bleeds
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cough
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muscle and joint pain
Serious side effects include: Candidiasis (fungal infection in the nose or throat), slow wound healing, eye problems such as glaucoma or cataracts, weakened immune system (immunodeficiency) which causes increased susceptibility to infections and adrenal insufficiency.
The inhaled form of mometasone for asthma may cause the following side effects:
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headache
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stuffy or runny nose
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dry throat
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swelling of nose, throat and sinuses
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flu-like symptoms
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painful menstrual periods
Serious side effects may include allergic reactions (anaphylaxis), increased risk of osteoporosis, glaucoma and cataracts, thrush in the mouth or throat, growth retardation in children, , adrenal insufficiency and weakened immune system which causes increased susceptibility to infections.
The topical (skin cream) version may cause:
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burning and itching at the application site
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acne
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changes in skin color
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dryness at the application site
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skin sores
The only serious side effect that is known with mometasone topical is adrenal insufficiency.
Pharmacology
Pharmacodynamics
Mometasone furoate reduces inflammation by causing several effects:
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Reversing the activation of inflammatory proteins
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Activating the secretion of anti-inflammatory proteins
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Stabilizing cell membranes
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Decreasing the influx of inflammatory cells
In addition to the glucocorticoid properties of mometasone furoate, it is a very potent agonist of the progesterone receptor as well as a partial agonist of the mineralocorticoid receptor.
Mechanism of action
Mometasone, like other corticosteroids, possesses anti-inflammatory, antipruritic, and vasoconstrictive properties. For allergies, corticosteroids reduce the allergic reactions in various types of cells (mastocytes and eosinophils) that are responsible for allergic reactions. Mometasone and other corticosteroids circulate in the blood easily, crossing cellular membranes and binding with cytoplasmic receptors, resulting in the transcription and synthesis of proteins. It also inhibits the actions of the enzyme cytochrome P450 2C8 which participates in the activity of monooxygenase.
The inflammation is reduced by decreasing the liberation of hydrolase acids of leukocytes, the prevention of the accumulation of in the sites of inflammation, the interference with the adhesion of leukocytes to capillary walls, the reduction of the permeability of the capillary membranes and consequently edema, the reduction of complementary components, inhibition of histamine and kinin liberation, and interference with scar tissue formation.
Although mometasone furoate does not have significant systemic immunomodulatory effects, it can be considered a local immunosuppressive drug because clinical studies have shown reductions (vs. baseline ) in neutrophils (a white blood cell) in the nasal mucosa. It could be also considered an antihistamine along with its glucocorticoid effects because it significantly reduces histamine and eosinophil cationic protein levels.
Pharmacokinetics
Metabolism
Extensive metabolic hepatic metabolism of mometasone furoate to multiple metabolites occurs. No principal metabolites are detectable in plasma. After in vitro incubation, one of the minor metabolites formed is furoate 6β-hydroxymometasone. In human hepatic microsomes, the formation of these metabolites is regulated by CYP3A4.
Mometasone
Mometasone by itself is a synthetic, glucocorticoid or corticosteroid that was never marketed.
Society and culture
Availability
As of 2016, mometasone furoate is available worldwide in formulations for nasal, oral inhalation, and topical administration, for human and veterinary use, either as a single active agent or in combination with other medications, under many brand names.
Combinations
The following combination medications are available as of 2022:| +
!Combination
!Commercial Name
!Notes |
| azelastine | Nasaflex | |
| clotrimazole and gentamicin | Mometamax, Mometavet | Veterinary use |
| clotrimazole and mupirocin | Derma Q | |
| florfenicol and terbinafine | Claro | Veterinary use |
| formoterol | Dulera, Hexaler Bronquial Duo, Zenhale | |
| fusidic acid | Bactirest-M, Dermotil Fusid, Momate-F | |
| gentamicin and posaconazole | Mometamax Ultra | Veterinary use |
| hydroquinone and tretinoin | Acnezac-MH | |
| miconazole | Elica M, Elica-M, and Sensicort-F | |
| mupirocin | Sensicort-B | |
| orbifloxacin and posaconazole | Posatex, Posatex voor honden, Posatex für Hunde | Veterinary use |
| salicylic acid | Cortimax-S, Elicasal, Elocom Plus, Elosalic, Mezo-S, Momate-S, Momesalic,
Momtas-S, Monsalic, Sensicort-S | |
| terbinafine | Cutizone-T, Mezo-T, MomelomTerbi-Humanity | |
| tiotropium | Tiomom |
