Misao (written: 操 or みさを in hiragana) is a unisex Japanese given name. Notable people with the name include:
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1886–1903, Japanese philosophy student and poet
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1913–2018, Japanese textile artist, weaver and educator
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1947–1972, Japanese murderer
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born 1961, Japanese biathlete
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1908–?, Japanese high jumper
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1903–1978, Japanese footballer
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born 1917, Japanese swimmer
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Misao, a Serbian publication
Fictional characters
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天野 美紗緒, a character in the anime series Magical Girl Pretty Sammy
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原田 実沙緒, protagonist of the manga series Black Bird
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日下部 みさお, a character in the manga series Lucky Star
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巻町 操, a character in the manga series Rurouni Kenshin
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水無神 操緒, a character in the light novel series Asura Cryin'
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防人 操, a character in the video game Gate Keepers
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財津 操, a character in the manga series First Love Limited