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Machaeriol A is one of a number of with a hexahydrocannabinol backbone, found in plants from the Machaerium family such as Machaerium multiflorum. While they are related in structure to tetrahydrocannabinols such as those from cannabis, the machaeriol compounds have opposite trans stereochemistry from THC and have no affinity for the psychoactive CB1 receptor. However, some derivatives are active at CB2, and they have also been found to have antibacterial, antifungal and antiparasitic actions, and have been investigated as for the development of potential anti-cancer drugs.
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