Lornoxicam, also known as chlortenoxicam, is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. It is available in oral and parenteral formulations.
It was patented in 1977 and approved for medical use in 1997.
Medical uses
Lornoxicam is used for the treatment of various types of pain, especially resulting from inflammatory diseases of the joints,
osteoarthritis, surgery,
sciatica, and other inflammations.
Contraindications
The drug is contraindicated in patients who must not take other NSAIDs, possible reasons including salicylate sensitivity, gastrointestinal bleeding and bleeding disorders, and severe impairment of heart, liver or kidney function. Lornoxicam is not recommended during pregnancy and breastfeeding and is contraindicated during the last third of pregnancy.
Adverse effects
Lornoxicam has side effects similar to other NSAIDs, most commonly mild ones like gastrointestinal disorders (
nausea and
diarrhea) and
headache. Severe but seldom side effects include bleeding,
and the extremely rare Stevens–Johnson syndrome.
Interactions
Interactions with other drugs are typical of NSAIDs. Combination with vitamin K antagonists like
warfarin increases the risk of bleeding. Combination with
ciclosporin can lead to reduced kidney function, and to acute kidney injury in rare cases. Lornoxicam can also increase the adverse effects of
lithium,
methotrexate and
digoxin and its derivatives. The effect of
,
and angiotensin II receptor antagonists can be reduced, but this is only relevant in patients with special risks like
heart failure. As with
piroxicam,
cimetidine can increase plasma levels but is unlikely to cause relevant interactions.
See also
