Lactide

 ( Lactones ) 

Lactide is the lactone cyclic compound ester derived by multiple esterification between two (usually) or more molecules from lactic acid (2-hydroxypropionic acid) or other hydroxy carboxylic acid. They are designated as dilactides, trilactides, etc., according to the number of hydroxy acid residues. All lactides are colorless or white solids. The dilactide derived from lactic acid has the formula . This lactide has attracted interest because it is derived from abundant renewable resources and is the precursor to a biodegradable Polylactic acid.

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Stereoisomers The dilactide derived from lactic acid can exist in three different stereoisomeric forms. This complexity arises because lactic acid is chiral. These enantiomers do not racemize readily.

All three stereoisomers undergo epimerisation in the presence of organic and inorganic bases in solution.

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Polymerization Lactide can be polymerization to polylactic acid (polylactide). Depending on the catalyst, syndiotactic or a heterotactic polymers can result. The resulting materials, polylactic acid, have many attractive properties.

(2025). 9780470293669, Wiley. ISBN 9780470293669

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