He was appointed sanitary inspector general of Lombardy, and introduced reforms in medical instruction and practice. The rank of councillor was conferred on him by the king of England, and later by the emperor of Austria, who employed him in 1795 for the regulation of the sanitary service of the army and as director general of the principal hospital of Vienna.
In 1804, he went to Vilnius University as professor of clinical medicine, and then for a period of time (1805–1808), he was personal physician to Czar Alexander I, and also professor at the medical and surgical academy of St. Petersburg. In 1808, he returned to Vienna, where he was professor of medicine at the University of Vienna, as well as director of the Allegemeines Krankenhaus.
He died in Vienna.
He stressed the importance of keeping accurate statistical records for hospitals. Reportedly, Frank's system of record compilation was used by obstetrician Ignaz Semmelweiss (1818–1865) to demonstrate the correlation between puerperal fever and unsanitary obstetrical practices. As a director of the Narrenturm, he was also responsible for allowing Franz Joseph Gall access to psychiatric patients in the mid-1780s—a major formative experience for Gall.
Frank is credited with being the first physician to describe clinical differences between diabetes mellitus and diabetes insipidus.Victor Cornelius Medvei (1993) The History of Clinical Endocrinology
The Frank – van Swieten Lectures, an international course about strategic information management in hospitals, that is organised by TU Braunschweig, University of Amsterdam, University of Heidelberg, UMIT at Hall near Innsbruck, Fachhochschule Heilbronn and Leipzig University, is named after him.
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