Isoserine is a non-proteinogenic α-hydroxy-β-amino acid, and an isomer of serine. Non-proteinogenic amino are not part of the genetic code of any known organism and are only present in proteins if added post-translationally. Isoserine has only been produced synthetically.
The first documented synthesis of isoserine in a laboratory setting was by Miyazawa et al., who published their results in 1976.
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