Isometheptene

 ( Alkene Derivatives ) 

Isometheptene (usually as isometheptene mucic acid) is a sympathomimetic amine sometimes used in the treatment of and tension headaches due to its vasoconstrictor properties; that is, it causes constriction (narrowing) of (arteries and veins). Along with paracetamol and dichloralphenazone, it is one of the constituents of Amidrine.

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Chemistry Isometheptene is a monounsaturated aliphatic secondary amine.

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Mechanism of action Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.

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See also

• 1,3-Dimethylbutylamine
• 1,4-Dimethylamylamine
• Heptaminol
• Iproheptine
• Methylhexanamine
• Octodrine
• Oenethyl
• Tuaminoheptane

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