Ibogamine

 ( Tryptamine Alkaloids ) 

Ibogamine is an anti-convulsant, anti-addictive, CNS stimulant alkaloid found in Tabernanthe iboga and Crepe Jasmine ( Tabernaemontana divaricata). Basic research related to how addiction affects the brain has used this chemical.

Ibogamine persistently reduced the self-administration of cocaine and morphine in rats. The same study found that ibogamine (40 mg/kg) and coronaridine (40 mg/kg) did not produce "any tremor effects in rats that differ significantly from saline control". While the related alkaloids ibogaine (20–40 mg/kg), harmaline (10–40 mg/kg) and desethylcoronaridine (10–40 mg/kg) were "obviously tremorgenic".

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Pharmacology Like ibogaine, it has seems to have similar pharmacology. It has effects on KOR, NMDAR, nAChR and serotonin sites. It also inhibits acetylcholinesterase and butyrylcholinesterase.

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Chemistry

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Synthesis Ibogamine can be prepared from one-step demethoxycarbonylation process through coronaridine.

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See also

• Coronaridine
• Ibogaine
• Ibogaline
• Tabernanthine
• Voacangine
• Ibogaminalog
• Harmaline

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