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Ibogainalog
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Ibogainalog ( IBG), also known as 9-methoxyibogaminalog, is a non-selective serotonin receptor modulator, serotonergic psychedelic, and of the group related to the but with a simplified chemical structure.


Pharmacology
+
(Ki)
6,911 ()
91% ()
(Ki)
170 ()
76% ()
(Ki)
6,043 ()
82% ()
(Ki)
9,309 ()
126% ()
(Ki)
35 ()
85% ()
670 (Ki)
18–85 ()
55–93% ()
169 (Ki)
11,130 or ()
58% or ()
810 (Ki)
4.0–19 ()
13–97% ()
(Ki)
>10,000 ()
(Ki)
>10,000 ()
(Ki)
7.1–8.8 ()
83–99% ()
(Ki)
335 ()
–17% ()
(Ki)
()
(Ki)
()
(Ki)
>10,000 ()
(Ki)
400 ()
(Ki)
20,000 ()
(Ki)
246,000 ()
39% @ 100μM
0% @ 100μM
Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs:

Ibogainalog acts as a non-selective serotonin receptor modulator, including as an of the 5-HT1B, 5-HT1F, 5-HT2A, and 5-HT6 receptors, as an agonist or antagonist of the serotonin 5-HT2B and 5-HT2C receptors, and as an of the serotonin 5-HT7 receptor. Unlike , IBG shows no activation of the or κ-opioid receptor agonism. In addition to its actions at serotonin receptors, IBG weakly inhibits certain nicotinic acetylcholine receptors. The drug also acts as a relatively weak serotonin reuptake inhibitor.

The drug produces the head-twitch response in animals and hence shows psychedelic-like effects. However, it has reduced and relatively weak hallucinogen-like effects compared to 5-MeO-DMT. Conversely, (TBG), a simplified analogue of and positional isomer of IBG, appears to be completely non-hallucinogenic. IBG shows comparable psychoplastogenic activity to ibogaine. In contrast to ibogaine, IBG and TBG appear to have much less or no potential for secondary to inhibition. However, TBG showed a better overall profile than IBG and was selected for development instead of IBG. IBG shows effects against and in animals that appear to be mediated by serotonin 5-HT2A receptor activation.

In early animal studies, ibogainalog was described as having enhanced -like, , and effects compared to ibogaine. It was also said to have -like effects.


Chemistry
IBG can be viewed as a conformationally restricted analogue of 5-MeO-DMT, whereas TBG can be viewed as a conformationally restricted analogue of 6-MeO-DMT. Owing to their simplified structures, the chemical syntheses of IBG and TBG are much more practical than the synthesis of ibogaine.


History
Ibogainalog was first described in the scientific literature by 1968.
(1975). 9780856080111, Wright-Scientechnica. .
Subsequently, it was studied and described in greater detail by David E. Olson and colleagues in the 2020s.


See also

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