IBMX

 ( Adenosine Receptor Antagonists ) 

IBMX (3-isobutyl-1-methylxanthine), like other xanthine, is both a:

1. competitive non-selective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, TNF inhibitor and leukotriene synthesis, and reduces inflammation and innate immunity, and
2. nonselective adenosine receptor antagonist.

As a phosphodiesterase inhibitor, IBMX has IC₅₀ = 2–50 μM and does not inhibit PDE8 or PDE9.