Gesenius is a surname. Notable people with the surname include:
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Justus Gesenius (1601–1673), German theologian
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Heinrich Friedrich Wilhelm Gesenius (1786–1842), German orientalist, Biblical critic, theologian, and Hebraist, famous for his Hebrew grammar text and his Biblical Hebrew lexicon
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Gesenius's Lexicon
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Gesenius-Kautzsch-Cowley