Essequibo is the largest traditional region of Guyana but not an administrative region of Guyana today. It may also refer to:
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Essequibo River, the largest river in Guyana
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Essequibo (colony), a former Dutch colony in what is now Guyana;
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Essequibo Islands-West Demerara, an administrative region of Guyana today
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Guayana Esequiba, also called Essequibo, Spanish name of a region administered and controlled by Guyana and internationally recognised as part of its territory but also claimed by Venezuela
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Essequibo cricket team, a former first-class cricket team in Guyana
