Diisopropylamine

 ( Alkylamines ) 

Diisopropylamine is a secondary amine with the chemical formula (Me₂CH)₂NH (Me = methyl). Diisopropylamine is a colorless liquid with an ammonia-like odor. Its lithium derivative, lithium diisopropylamide, known as LDA is a widely used reagent.

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Reactions and use Diisopropylamine is a common amine nucleophile in organic synthesis. Because it is bulky, it is a more selective nucleophile than other similar amines, such as dimethylamine.

It reacts with organolithium reagents to give lithium diisopropylamide (LDA). LDA is a strong base, non-nucleophilic base

The main commercial applications of diisopropylamine is as a precursor to the herbicide, diallate and triallate as well as certain used in the vulcanization of rubber.

It is also used to prepare N, N-diisopropylethylamine (Hünig's base) by alkylation with diethyl sulfate.

The bromide salt of diisopropylamine, diisopropylammonium bromide, is a room-temperature organic ferroelectric material.

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Preparation Diisopropylamine, which is commercially available, may be prepared by the reductive amination of acetone with ammonia using a modified copper oxide, generally copper chromite, as a catalysis:

Diisopropylamine can be dried by distillation from potassium hydroxide () or drying over sodium wire.

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Toxicity Diisopropylamine causes burns by all exposure routes. Inhalation of high concentrations of its vapor may cause symptoms like headache, dizziness, tiredness, nausea and vomiting.

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