Diadiaphorus is an extinct genus of Litopterna mammal from the Miocene of Argentina (Ituzaingó, Pinturas, Chiquimil and Santa Cruz Formations) and Bolivia (Nazareno Formation), South America.
It had three toes, only one of which touched the ground. This toe had a large claw derived from the median digit, the two outer toes were rudimentary, much like those of early horses such as Merychippus. Unlike horses, however, Diadiaphorus lacked fused limb bones. Its skull was short and had a relatively large brain cavity. The neck of Diadiaphorus was shortened as well. Judging from its low molars, Diadiaphorus ate soft vegetation, such as leaves.
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