Product Code Database
Dexibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It is the active dextrorotatory enantiomer of ibuprofen. Most ibuprofen formulations, as well as other drugs of the profen drug class, contain a racemic mixture of both isomers.
Dexibuprofen is a chiral switch of racemic ibuprofen. The chiral carbon in dexibuprofen is assigned an absolute configuration of ( S) per the Cahn–Ingold–Prelog rules. Dexibuprofen is also called ( S)-(+)-ibuprofen.
Ibuprofen is an α-arylpropionic acid used largely in the treatment of rheumatoid arthritis and widely used over-the counter drug for headache and minor pains. This drug has a Stereocenter and exists as a pair of Enantiomer. ( S)-Ibuprofen, the Eudysmic ratio, is responsible for the desired therapeutic effect. The inactive ( R)-enantiomer, the distomer, undergoes a unidirectional chiral inversion to give the active ( S)-enantiomer, the former acting as a prodrug for the latter. That is, when the ibuprofen is administered as a racemate the distomer is converted in vivo into the eutomer while the latter is unaffected.
|
|
