Conopharyngine

 ( Alkaloids Found In Iboga ) 

Conopharyngine is the major alkaloid present in the leaves and stem-bark of Tabernaemontana pachysiphon and Conopharyngia durissima. It is closely related voacangine and coronaridine. Conopharyngine pseudoindoxyl, a derivative of it, is also found in the same plant Tabernaemontana pachysiphon.

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Pharmacology It possess central nervous system stimulant activity and produces bradycardia and hypotension in cats. It has weak acetylcholinesterase inhibitory activity and significantly increases hexobarbitone induced sleeping time.

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Toxicity It has low intravenous toxicity in mice ( = 143 mg/kg).

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See also

• Ibogaline

Categories: Alkaloids Found In Iboga, Methoxy Compounds, Heterocyclic Compounds With 5 Rings, Methyl Esters, Nitrogen Heterocycles, Tryptamine Alkaloids, Catechol Ethers

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