Coluracetam

 ( Racetams ) 

Coluracetam (INN; development code BCI-540; formerly MKC-231) is a purported nootropic drug of the racetam family. It contains a chemical group that is a bioisostere of the Tacrine family. It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California. Qualifying Therapeutic Discovery Project Grants for the State of California, IRS.gov. Findings from phase IIa have suggested that it would be a potential medication for comorbidity MDD with generalized anxiety disorder (GAD). BrainCells Inc. Announces Results From Exploratory Phase 2a Trial of BCI-540 BrainCells Inc is currently out-licensing the drug for this purpose. BCI-540 (coluracetam) | BrainCells It may also have potential use in prevention and treatment of ischemia retinopathy and and optic nerve injury.

Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP), and is considered a potential therapeutic drug for schizophrenia.

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Mechanism of action Coluracetam enhances high-affinity choline reuptake (HACU), which is the rate-limiting step of acetylcholine (ACh) biosynthesis. Studies have shown coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic . Subsequent studies have shown that it may induce long-lasting nootropic effects in cholinergic neurotoxin-treated rats by changing the choline transporter regulation system.

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Legality

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Australia Coluracetam is a schedule 4 substance in Australia under the Poisons Standard (February 2020). Poisons Standard February 2020. comlaw.gov.au A schedule 4 substance is classified as "Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on prescription."

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See also

• Piracetam
• Tricyanoaminopropene

Categories: Racetams, Acetamides, Furans, Experimental Drugs

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