Clonixin is a nonsteroidal anti-inflammatory drug (NSAID). It also has analgesic, antipyretic, and platelet-inhibitory actions. It is used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.
Synthesis
Clonixeril
The glyceryl ester of clonixin, clonixeril, is also an NSAID. It was prepared by a somewhat roundabout method.
Clonixin was reacted with chloroacetonitrile and
triethylamine to give
2. Heating with potassium carbonate and glycerol acetonide displaced the
activating group to produce ester
3, which was deblocked in
acetic acid to produce clonixeril (
4).
See also
