Catharanthalog ( CAG) is a non- serotonin receptor modulator of the ibogalog group related to the iboga alkaloid catharanthine but with a simplified chemical structure. It is known to act as a serotonin 5-HT2A receptor partial agonist. The drug produces analgesic-like effects in a neuropathic pain animal model in rodents that can be reduced by the serotonin 5-HT2A receptor antagonist ketanserin. Catharanthalog is said to have relatively low blood–brain barrier permeability owing to relatively low lipophilicity. It does not produce the head-twitch response, a behavioral proxy of psychedelic drug effects, in rodents. The drug was first described in the scientific literature by 2025.
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