Carmustine, sold under the brand name BiCNU among others, is a medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent.
Description
Carmustine is an orange-yellow solid medication used mainly for
chemotherapy. It is a
nitrogen mustard β-chloro-nitrosourea compound.
Mechanism of action
As an
Alkylation, carmustine can form interstrand crosslinks in
DNA, which prevents DNA replication and DNA transcription.
Uses
Carmustine is used as an alkylating agent to treat several types of
brain cancer including
glioma, glioblastoma multiforme,
medulloblastoma and
astrocytoma,
multiple myeloma, and
lymphoma (Hodgkin's and non-Hodgkin).
Carmustine is sometimes used in conjunction with alkyl guanine transferase (AGT) inhibitors, such as O6-benzylguanine. The AGT-inhibitors increase the efficacy of carmustine by inhibiting the direct reversal pathway of DNA repair, which will prevent formation of the interstrand crosslink between the N1 of guanine and the N3 of cytosine.
It is also used as part of a chemotherapeutic protocol in preparation for hematological stem cell transplantation, a type of bone marrow transplant, in order to reduce the white blood cell count in the recipient.
Implants
In the treatment of
, the U.S. Food and Drug Administration (FDA) approved
biodegradable discs infused with carmustine (
Gliadel).
They are implanted under the skull during a surgery called a
craniotomy. The disc allows for controlled release of carmustine in the extracellular fluid of the brain, thus eliminating the need for the encapsulated drug to cross the blood-brain barrier.
Production
Carmustine for injection was marketed under the name BiCNU by Bristol-Myers Squibb
and now by Emcure Pharmaceuticals.
In India it is sold under various brand names, including Consium.. The product is available as a generic version with other manufacturers offering the product licensed in the US and EU markets.
See also
External links
