Product Code Database
Bambuterol (INN) is a long-acting β adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline. Commercially, the AstraZeneca pharmaceutical company produces and markets bambuterol as Bambec and Oxeol. (2025). 9780853698401, Pharmaceutical Press. ISBN 9780853698401
It is not available in the U.S.
Bambuterol acts as a cholinesterase inhibitor, and can prolong the duration of action of suxamethonium (succinylcholine) and other drugs whose breakdown in the body depends on cholinesterase function. Butyrylcholinesterase activity returns to normal approximately two weeks after bambuterol is stopped. It can also enhance the effects of non-depolarizing neuromuscular blockers, such as vecuronium bromide.
Synthesis
The reaction between 3',5'-Dihydroxyacetophenone 51863-60-6 (1) and Dimethylcarbamoyl chloride 79-44-7 (2) gives 5-Acetyl-1,3-phenylene bis(dimethylcarbamate) 81732-48-1 (3). Halogenation with bromine led to 5-(Bromoacetyl)-1,3-phenylene bis(dimethylcarbamate) 81732-49-2 (4). Treatment with N-(tert-Butyl)benzylamine 3378-72-1 (5) afforded 81732-47-0 (6). Catalytic hydrogenation completed the synthesis of bambuterol (7).
|
|
