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Babesia bigemina is a species of Alveolata belonging to the phylum Apicomplexa and the family Babesiidae, a type of protozoan parasite. In cattle, it causes babesiosis, also called "Texas fever". Its length is 4–5 μm and its width is 2–3 μm. Usually, it has an oval shape. In blood cells, it is located midsagittally and can reach up to two-thirds of the diameter of the blood cell in size. It is transmitted by Boophilus ticks which are prevalent in the tropics. The genome for B. bigemina is incomplete and unassembled.
It is the causative agent of babesiosis or cattle fever, a devastating disease to naive cattle with the ability to quickly kill its hosts. Ticks in the genus Rhipicephalus ( Rh. microplus, Rh. boophilus) are main intermediate hosts and vectors. (2026). 9780128222652 ISBN 9780128222652 Because tick populations persist globally, B. bigemina prevalence has also persisted, causing hardship and economic loss to the cattle industry .
The sporozoites invade the red blood cells of the cow and begin to asexually reproduce by binary fission and the parasite develops into a trophozoite stage. This is followed by the production of male and female gametes. If another tick bites the cow, the blood meal may containing gametes. In the midgut of the tick, the gametes will combine and create a zygote and migrate toward the salivary glands of the tick where sporogony will occur and sporozoites will develop. The cycle will then repeat.
B. bigemina had a higher rate of infection in calves when compared to its counterparts within the Babesia genus, which means that young calves, who are naive and have not developed many immunologic responses, are very susceptible to this pathogen and die after infection. This makes it difficult to raise cattle in areas inhabited by Rhipicephalus ticks. This highlights the need for alternative methods of tick population control, as control the vector of the disease controls the pathogen.
Hemolytic anemia is the condition by which red blood cells are unable to reproduce as fast as they are being destroyed, oftentimes causing a major fever, nausea, fatigue, etc. If caught early, the disease can be treated with the use of diminazene, although it is sometimes difficult to catch in cows that are sick and for ranchers that do not have access to diagnostic testing for detetction of Babesia bigemina. In previous decades, the methods of detection involved serosurveys for antibody detection, as well as blood smears. Although PCR assays have been developed to detect Babesia bigemina in extracted DNA samples, and many sequencing efforts have been put into development in order to determine phylogenetic diversity of the pathogen.
The ecological complexity of ecosystems are subject to shifting by the introduction of invasive tick species and pathogens spreading around the world, like the Rhipicephalus spp. that are invasive to southern Texas. Currently, the only ways to eradicate tick populations involves chemical pesticides, but these are not globally regulated and are becoming less and less effective over the years. Evolutionary resistance mutations in the voltage-gated sodium channel (VGSC) genes that lead to amino acid replacements and encode protein changes are becoming more prevalent, so the need for alternative methods of control is on the rise so that the associated pathogens can also be controlled.
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