Ānantarya karma (Sanskrit) or Ānantarika kamma (Pāli) are the most serious offences in Buddhism that, at death, through the overwhelming karmic strength of any single one of them, bring immediate disaster. Both Buddhists and non-Buddhists must avoid them at all costs. Such offenses prevent perpetrators from attaining any of the stages of enlightenment and from ordaining into the Sangha. The offences are: Triplegem glossary
Ānantarika kamma is considered so serious that even Amitabha Buddha abandoned all hope. His 18th Vow reads:
Those who have committed any of the five acts of Ānantarika kamma are said to be reborn in the naraka of Avīci, the very lowest of all the Hells of Buddhism.
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