Amanullin is a cyclic peptide. It is an amatoxin, all of which are found in several members of the mushroom genus Amanita. The oral of amanullin is approximately 20 mg/kg in mice; however, it is non-toxic in humans.
Toxicology
Like other
amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing
cytolysis of
(liver cells).
See also
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