Copper-catalyzed Multi-component Reactions: Synthesis Of Nitrogen-containing Polycyclic Compounds

 ( Book Product ) 

A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct

• Copper-catalyzed Multi-component Reactions: Synthesis Of Nitrogen-containing Polycyclic Compounds available on November 30 2016 from Indigo for 167.95
  
• ISBN bar code 9783642267017 ξ1 registered November 30 2016
  
• Product category is Book

• Sku # 978364226701
  

Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.

^ Copper-catalyzed Multi-component Reactions: Synthesis Of Nitrogen-containing Polycyclic Compounds Indigo. ISBN 9783642267017 (revised Nov 2016)