Product Code Database
This historic book may have numerous typos and missing text
Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1913 edition. Excerpt: ...O CH2:CH.CH2.CeH3(OCOCH3).OCH3-HOOC.CH2.C6H3(OCOCH3).OCH3 Y HOOC.CH2.C6H3(OCH3)2 HOOC.CH2.C6H (OH).OCH3 Y (ch30)2.c6h3.ch2.c0c1 By condensation of the acid chloride with the amine in the presence of caustic alkali, homoveratroyl-homoveratrylamine is produced, which, when heated with phosphorus pentoxide and xylene, yields dihydropapaverine. The dihydropapaverine is then converted into the methiodide and the methyl derivative finally reduced by tin and hydrochloric acid to (//-laudanosine. Narcotine, C22H23O7N, is a weak tertiary base, which is insoluble in cold solutions of the caustic alkalies, but is soluble in hot solutions of the alkalies, the salts obtained being formed by the splitting of a lactone ring in the molecule, with consequent assumption of the elements of water. It may be shown by application of the usual reactions that three methoxy groups are present, and also that the nitrogen atom is in combination with a methyl group. The chief decomposition products obtained from narcotine are opianic acid, C10H10O5, and hydrocotarnine, C12H15O3N, which are formed as products of hydrolysis; meconine, C10H10O4, and hydrocotarnine, obtained on reduction; and opianic acid and cotarnine, C12H15NO4) produced when the alkaloid is oxidized with nitric acid. Hemipinic acid, C10H10O0, opianic acid, C10H10O5, and meconine, C10H10O4, are three compounds, which are intimately related, since oxidation of opianic acid yields hemipinic acid, and reduction yields meconine. They are thus related as dibasic acid, aldehyde acid, and internal anhydride of the corresponding alcohol acid. Hemipinic acid is dibasic, and gives an anhydride, consequently its carboxyl groups must be in the ortho-position to each other. It contains two methoxy groups, and on...
|
|
