5 HTP NUTRITIONALLY SUPPLIES THE IMMEDIATE METABOLICPRECURSOR TO SEROTONINDietary supplementation may enhance levels of: Serotonin, Melatonin,Catecholamines
5 HTP NUTRITIONALLY SUPPLIES THE IMMEDIATE METABOLICPRECURSOR TO SEROTONINDietary supplementation may enhance levels of: Serotonin, Melatonin,Catecholamines, Endorphins May positively enhance mood May enhance the sleep cycle May reduce discomfort in patients with chronic pain May regulate feeding patterns and have positive bariatric (weight management) effects5-Hydroxytryptophan (5-HTP) is the immediate precursor in the biosynthesisof the neurotransmitter 5-hydroxytryptamine (5 HT or serotonin). 5-HT issynthesized from the amino acid L-tryptophan. 5-HTP has replaced the use ofL-tryptophan in the United States. In 1989, patients taking L-tryptophandeveloped a negative and debilitating reaction called eosinophilia-myalgiasyndrome. Upon further study, it was determined that the culprit was not theL-tryptophan. It was actually a bacterial contaminant in the formula.L-tryptophan products associated with the syndrome were found to come fromgenetically modified bacterial recombinant production methods. Even though L-tryptophan was proven safe, it never recovered from this incident. 5-HTP wascreated to fill the gap created by the removal of L-tryptophan in themarketplace.Small amounts of 5-HTP, as well as serotonin, are found in bananas,tomatoes, plums, avocados, eggplant, walnuts and pineapples. A commoncommercial source of 5-HTP is Griffonia simplicifolia, a relative to carob.5-HTP&rsquo,s possible pain reduction benefit comes from its conversion toserotonin and to the observed effect of raising beta-endorphin and plateletmet-enkephalin levels.Serum leptin levels increased following 5-HTP injection in mice. This mayexplain 5-HTP&rsquo,s beneficial effect on weight management. Additionally,5-HTP has been shown to reduce carbohydrate intake.Contraindications: Patients on MAOIs (approved 2 weeks after discontinuation) Patients with carcinoid tumors Should not be used concurrently with medications such as SSRIs, tricyclic antidepressants, MAOIs. Should not be use
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