Casper and his ghostly trio of uncles, Fatso, Stinkie and Stretch, run smack into their natural enemies--good little Wendy and her family of Witless Witches, Gert, Gabby and Fanny (featuring Cathy Moriarty, Shelley Duvall and Teri Garr, respectively). Everyone knows that witches and ghosts don't get along--except Casper and Wendy. Against all odds, the happily haunted duo tries to be friends. But their loyalty is tested when the witches come under attack by the grotesquely greedy and eccentrically evil warlock Desmond Spellman (George Hamilton) and his bumbling henchmen--and it's up to Wendy and Casper to prove that witches and ghosts can join forces and get along, after all!
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