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Tag Wiki 'Lactation'.

Lactation describes the secretion of from the and the period of time that a lactates to feed her young. The process naturally occurs with all sexually mature , although it may predate mammals. The process of feeding milk in all animals (including humans) is called nursing, and in humans it is also called . Newborn infants often produce some milk from their own breast tissue, known colloquially as witch's milk.

In most species, lactation is a sign that the female has been pregnant at some point in her life, although it can happen without pregnancy. Nearly every species of mammal has ; except for , egg-laying mammals, which instead release milk through ducts in the abdomen. In only one of mammal, the Dayak fruit bat from , is milk production a normal .

Galactopoiesis is the maintenance of milk production. This stage requires . is critical for the milk let-down reflex in response to . is milk production unrelated to nursing. It can occur in males and females of many mammal species as result of hormonal imbalances such as hyperprolactinaemia.

The chief function of a lactation is to provide and immune protection to the young after birth. Due to lactation, the mother-young pair can survive even if food is scarce or too hard for the young to attain, expanding the environmental conditions the species can withstand. The costly investment of energy and resources into milk is outweighed by the benefit to offspring survival.
(2022). 9781421420424
In almost all mammals, lactation induces a period of (in humans, lactational amenorrhea), which serves to provide the optimal for survival of the offspring.


Hormonal influences
From the eighteenth week of (the second and third trimesters), a woman's body produces that stimulate the growth of the system in the :

  • influences the growth in size of and lobes; high levels of progesterone inhibit lactation before birth. Progesterone levels drop after birth; this triggers the onset of copious milk production.
    (2022). 9780912500928, La Leche League International.
  • stimulates the milk duct system to grow and differentiate. Like progesterone, high levels of estrogen also inhibit lactation. Estrogen levels also drop at delivery and remain low for the first several months of breastfeeding. Breastfeeding mothers should avoid estrogen-based birth control methods, as a spike in estrogen levels may reduce a mother's milk supply.
  • contributes to the increased growth and differentiation of the alveoli, and also influences differentiation of ductal structures. High levels of prolactin during pregnancy and breastfeeding also increase insulin resistance, increase growth factor levels (IGF-1) and modify lipid metabolism in preparation for breastfeeding. During lactation, prolactin is the main factor maintaining of the ductal epithelium and regulating milk production through osmotic balance.
  • Human placental lactogen (HPL) – from the second month of pregnancy, the releases large amounts of HPL. This hormone is closely associated with prolactin and appears to be instrumental in breast, nipple, and areola growth before birth.
  • Follicle stimulating hormone (FSH), luteinizing hormone (LH), and human chorionic gonadotropin (hCG), through control of estrogen and progesterone production, and also, by extension, prolactin and growth hormone production, are essential.
  • (GH) is structurally very similar to prolactin and independently contributes to its galactopoiesis.
  • Adrenocorticotropic hormone (ACTH) and such as have an important lactation inducing function in several animal species, including humans. Glucocorticoids play a complex regulating role in the maintenance of tight junctions.
  • Thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH) are very important galactopoietic hormones whose levels are naturally increased during pregnancy.
  • contracts the of the during and after birth, and during orgasm(s). After birth, oxytocin contracts the smooth muscle layer of band-like cells surrounding the alveoli to squeeze the newly produced milk into the duct system. Oxytocin is necessary for the milk ejection reflex, or let-down, in response to suckling, to occur.

It is also possible to induce lactation without pregnancy through combinations of birth control pills, , and milk expression using a breast pump.

Secretory differentiation
During the latter part of pregnancy, the woman's breasts enter into the Secretory Differentiation stage. This is when the breasts make (see below), a thick, sometimes yellowish fluid. At this stage, high levels of progesterone inhibit most milk production. It is not a medical concern if a pregnant woman leaks any colostrum before her baby's birth, nor is it an indication of future milk production.

Secretory activation
At , prolactin levels remain high, while the delivery of the placenta results in a sudden drop in progesterone, estrogen, and HPL levels. This abrupt withdrawal of progesterone in the presence of high prolactin levels stimulates the copious milk production of Secretory Activation.

When the breast is stimulated, prolactin levels in the blood rise, peak in about 45 minutes, and return to the pre-breastfeeding state about three hours later. The release of prolactin triggers the cells in the alveoli to make milk. Prolactin also transfers to the breast milk. Some research indicates that prolactin in milk is greater at times of higher milk production, and lower when breasts are fuller, and that the highest levels tend to occur between 2 a.m. and 6 a.m.

Other hormones—notably insulin, thyroxine, and cortisol—are also involved, but their roles are not yet well understood. Although biochemical markers indicate that Secretory Activation begins about 30–40 hours after birth, mothers do not typically begin feeling increased breast fullness (the sensation of milk "coming in the breast") until 50–73 hours (2–3 days) after birth.

is the first milk a breastfed baby receives. It contains higher amounts of white blood cells and than mature milk, and is especially high in (IgA), which coats the lining of the baby's immature intestines, and helps to prevent pathogens from invading the baby's system. Secretory IgA also helps prevent food allergies.

(2022). 9780316779241, Little, Brown. .
Over the first two weeks after the birth, colostrum production slowly gives way to mature breast milk.

Autocrine control - Galactopoiesis
The hormonal control system drives milk production during pregnancy and the first few days . When the milk supply is more firmly established, (or local) control system begins.

During this stage, the more that milk is removed from the breasts, the more the breast will produce milk. Research also suggests that draining the breasts more fully also increases the rate of milk production. Thus the milk supply is strongly influenced by how often the baby feeds and how well it is able to transfer milk from the breast. Low supply can often be traced to:

  • not feeding or often enough
  • inability of the infant to transfer milk effectively caused by, among other things:
    • jaw or mouth structure deficits
    • poor latching technique
    • premature birth
    • drowsiness in the baby, due to illness, medication or recovery from medical procedures
  • rare maternal endocrine disorders
  • hypoplastic breast tissue
  • inadequate calorie intake or malnutrition of the mother

Milk ejection reflex
This is the mechanism by which milk is transported from the breast alveoli to the nipple. Suckling by the baby stimulates the paraventricular nuclei and supraoptic nucleus in the , which signals to the posterior to produce . Oxytocin stimulates contraction of the myoepithelial cells surrounding the alveoli, which already hold milk. The increased pressure causes milk to flow through the duct system and be released through the nipple. This response can be conditioned e.g. to the cry of the baby.

Milk ejection is initiated in the mother's breast by the act of suckling by the baby. The milk ejection reflex (also called let-down reflex) is not always consistent, especially at first. Once a woman is conditioned to nursing, let-down can be triggered by a variety of stimuli, including the sound of any baby. Even thinking about breastfeeding can stimulate this reflex, causing unwanted leakage, or both breasts may give out milk when an infant is feeding from one breast. However, this and other problems often settle after two weeks of feeding. Stress or anxiety can cause difficulties with breastfeeding. The release of the hormone leads to the milk ejection or let-down reflex. Oxytocin stimulates the muscles surrounding the breast to squeeze out the milk. Breastfeeding mothers describe the sensation differently. Some feel a slight tingling, others feel immense amounts of pressure or slight pain/discomfort, and still others do not feel anything different. A minority of mothers experience a dysphoric milk ejection reflex immediately before let-down, causing anxiety, anger or nausea, amongst other negative sensations, for up to a few minutes per feed.

A poor milk ejection reflex can be due to sore or cracked nipples, separation from the infant, a history of breast , or tissue damage from prior . If a mother has trouble breastfeeding, different methods of assisting the milk ejection reflex may help. These include feeding in a familiar and comfortable location, massage of the breast or back, or warming the breast with a cloth or shower.

Milk ejection reflex mechanism
This is the mechanism by which milk is transported from the breast alveoli to the nipple. Suckling by the baby innervates slowly-adapting and rapidly-adapting that are densely packed around the region. The electrical impulse follows the spinothalamic tract, which begins by innervation of fourth intercostal nerves. The electrical impulse then ascends the posterolateral tract for one or two vertebral levels and synapses with second-order neurons, called tract cells, in the posterior dorsal horn. The tract cells then decussate via the anterior white commissure to the anterolateral corner and ascend to the supraoptic nucleus and paraventricular nucleus in the , where they synapse with oxytocinergic third-order neurons. The somas of these neurons are located in the hypothalamus, but their axon and axon terminals are located in the and of the posterior pituitary, respectively. The oxytocin is produced in the neuron's soma in the supraoptic and paraventricular nuclei, and is then transported down the infundibulum via the hypothalamo-neurohypophyseal tract with the help of the carrier protein, , to the pars nervosa of the posterior pituitary, and then stored in , where they are stored until the synapse between second- and third-order neurons.

Following the electrical impulse, oxytocin is released into the bloodstream. Through the bloodstream, oxytocin makes its way to myoepithelial cells, which lie between the extracellular matrix and luminal epithelial cells that also make up the alveoli in breast tissue. When oxytocin binds to the myoepithelial cells, the cells contract. The increased intra-alveolar pressure forces milk into the lactiferous sinuses, into the lactiferous ducts (a study found that lactiferous sinuses may not exist. If this is true then milk simply enters the lactiferous ducts), and then out the nipple.

A surge of oxytocin also causes the uterus to contract. During breastfeeding, mothers may feel these contractions as afterpains. These may range from period-like cramps to strong labour-like contractions and can be more severe with second and subsequent babies.Breastfeeding Answers Made Simple, Nancy Mohrbacher, IBCLC, FILCA
(2022). 9781869417130, Random House NZ.

Without pregnancy, induced lactation, relactation
In humans, induced lactation and relactation have been observed frequently in some cultures, and demonstrated with varying success in adoptive mothers and .E. Goljan, Pathology, 2nd ed. Mosby Elsevier, Rapid Review Series.Wilson-Clay, Barbara (1996). "Induced Lactation" . The American Surrogacy Center. It appears plausible that the possibility of lactation in women (or females of other species) who are not biological mothers does confer an evolutionary advantage, especially in groups with high maternal mortality and tight social bonds. The phenomenon has been also observed in most primates, in some lemurs, and in dwarf mongooses.

Lactation can be induced in humans by a combination of physical and psychological stimulation, by drugs, or by a combination of those methods. Several protocols for inducing lactation were developed by Dr. Jack Newman and Lenore Goldfarb and are commonly called the Newman-Goldfarb protocols. The "regular protocol" involves the use of birth control pills to mimic the hormone levels of pregnancy with to stimulate milk production, followed by discontinuing the birth control and the introducing use of a double electric breast pump to induce milk production. Additional protocols exist to support an accelerated timeline and to support induced lactation in menopausal parents.

Some couples may stimulate lactation outside of pregnancy for .

Rare accounts of (as distinct from ) exist in historical medical and anthropological literature, although the phenomenon has not been confirmed by more recent literature.

is a drug that can induce lactation.

recognized that mammary glands seemed to have developed specifically from cutaneous glands, and hypothesized that they evolved from glands in brood pouches of fish, where they would provide nourishment for eggs. The latter aspect of his hypothesis has not been confirmed; however, more recently the same mechanism has been postulated for early .

As all mammals lactate, lactation must have evolved before the last common ancestor of all mammals, which places it at a minimum in the Middle or Late Triassic when monotremes diverged from therians. O. T. Oftedal has argued that evolved a proto-lacteal fluid in order to keep eggs moist, an adaption necessitated due to diapsids parchment shelled eggs which are more vulnerable to evaporation and dehydration than the mineralized eggs produced by some sauropsids. This protolacteal fluid became a complex, nutrient-rich milk which then allowed a decline in egg size by reducing the dependence on a large yolk in the egg.20 The evolution of lactation is also believed to have resulted in the more complex dentition seen in mammals, as lactation would have allowed the prolonged development of the jaw before the eruption of teeth.

During early evolution of lactation, the secretion of milk was through pilosebaceous glands on mammary patches, analogous to the areola, and hairs on this patch transported the nourishing fluids to the hatchlings as is seen in . The development of the nipple occurred in the mammal lineages that diverged after monotremes, and .

Occurrence outside Mammalia
Another well known example of nourishing young with secretions of glands is the of birds. As in mammals, this also appears to be directed by prolactin. Other birds such as and utilize similar feeding techniques.

The ( Symphysodon) is known for (biparentally) feeding their offspring by epidermal mucus secretion. A closer examination reveals that, as in mammals and birds, the secretion of this nourishing fluid may be controlled by prolactin. Similar behavior is seen in at least 30 species of .

Lactation is also the hallmark of adenotrophic viviparity - a breeding mechanism developed by some insects, most notably . The single egg of the tsetse develops into a larva inside the uterus where it is fed by a milky substance secreted by a milk gland inside the uterus. The species Diploptera punctata is also known to feed their offspring by milky secretions.

, an ant-mimicking species of Southeast Asia, also lactates. It nurses its offspring for about 38 days, although they are able to forage on their own after 21 days. Blocking nursing immediately after birth resulted in complete mortality of the offspring, whereas blocking it 20 days after birth resulted in increased foraging and reduced survival. This form of lactation may have evolved from production of .

See also

External links

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