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The integumentary system is the set of organs forming the outermost layer of an animal's body, comprising the , , scales, , , , and nails. It acts as a protective physical barrier between the external environment and the internal environment. Additionally, it maintains water balance, protects the deeper tissues, excretes waste, regulates , and contains the that detect pain, sensation, pressure, and temperature.

The skin (integument) is a composite organ, made up of at least two major layers of tissue: the outermost epidermis and the inner , which are separated by a basement membrane (comprising and ). The epidermis comprises five layers: the , stratum granulosum, and . Where the skin is thicker, such as in the palms and soles, there is an extra layer of skin between the stratum corneum and the stratum granulosum known as the . The dermis comprises two sections, the papillary and reticular layers, and contains connective tissues, blood vessels, glands, follicles, , sensory nerve endings, and muscular tissue. Between the integument and the deep body musculature there is a transitional subcutaneous zone, the .


Structure

Skin
The skin is one of the largest organs of the body. In humans, it accounts for about 12 to 15 percent of total body weight and covers 1.5 to 2 m2 of surface area.
(2025). 9780321505897, Pearson/Benjamin Cummings.

The skin (integument) is a composite organ, made up of at least two major layers of tissue: the epidermis and the .

(2025). 9781259700910
The epidermis is the outermost layer, providing the initial barrier to the external environment. It is separated from the dermis by the basement membrane ( and ). The epidermis contains and gives color to the skin. The deepest layer of the epidermis also contains . Beneath this, the dermis comprises two sections, the papillary and reticular layers, and contains connective tissues, blood vessels, glands, follicles, , sensory nerve endings, and muscular tissue.

Between the integument and the deep body musculature there is a transitional subcutaneous zone made up of very loose connective and , the . Substantial bundles anchor the dermis to the hypodermis in a way that permits most areas of the skin to move freely over the deeper tissue layers.


Epidermis
The is the strong, superficial layer that serves as the first line of protection against the outer environment. The human epidermis is composed of stratified squamous epithelial cells, which further break down into four to five layers: the , stratum granulosum, and . Where the skin is thicker, such as in the palms and soles, there is an extra layer of skin between the stratum corneum and the stratum granulosum called the . The epidermis is regenerated from the stem cells found in the basal layer that develop into the corneum. The epidermis itself is devoid of blood supply and draws its nutrition from its underlying dermis.

Its main functions are protection, absorption of nutrients, and . In structure, it consists of a keratinized stratified squamous epithelium; four types of cells: , , , and .

The predominant cell , which produces , a fibrous protein that aids in skin protection, is responsible for the formation of the epidermal water barrier by making and secreting . The majority of the skin on the human body is keratinized, with the exception of the lining of , such as the inside of the mouth. Non-keratinized cells allow water to "stay" atop the structure.

The protein keratin stiffens epidermal tissue to form . Nails grow from a thin area called the nail matrix at an average of 1 mm per week. The lunula is the crescent-shape area at the base of the nail, lighter in color as it mixes with matrix cells. Only have nails. In other vertebrates, the keratinizing system at the terminus of each digit produces claws or hooves.

The epidermis of vertebrates is surrounded by two kinds of coverings, which are produced by the epidermis itself. In and aquatic , it is a thin mucus layer that is constantly being replaced. In terrestrial vertebrates, it is the (dead keratinized cells). The epidermis is, to some degree, glandular in all vertebrates, but more so in and . Multicellular epidermal glands penetrate the dermis, where they are surrounded by blood capillaries that provide nutrients and, in the case of endocrine glands, transport their products.


Dermis
The dermis is the underlying connective tissue layer that supports the epidermis. It is composed of dense irregular connective tissue and areolar connective tissue such as a collagen with arranged in a diffusely bundled and woven pattern.

The dermis has two layers: the papillary dermis and the reticular layer. The papillary layer is the superficial layer that forms finger-like projections into the epidermis (dermal papillae), and consists of highly vascularized, loose connective tissue. The reticular layer is the deep layer of the dermis and consists of the dense irregular connective tissue. These layers serve to give elasticity to the integument, allowing stretching and conferring flexibility, while also resisting distortions, wrinkling, and sagging. The dermal layer provides a site for the endings of blood vessels and nerves. Many are also stored in this layer, as are the bases of integumental structures such as , , and .


Hypodermis
The hypodermis, otherwise known as the subcutaneous layer, is a layer beneath the skin. It invaginates into the dermis and is attached to the latter, immediately above it, by collagen and elastin fibers. It is essentially composed of a type of cell known as adipocytes, which are specialized in accumulating and storing fats. These cells are grouped together in lobules separated by connective tissue.

The hypodermis acts as an energy reserve. The fats contained in the adipocytes can be put back into circulation, via the venous route, during intense effort or when there is a lack of energy-providing substances, and are then transformed into energy. The hypodermis participates, passively at least, in thermoregulation since fat is a heat insulator.


Functions
The integumentary system has multiple roles in . All body systems work in an interconnected manner to maintain the internal conditions essential to the function of the body. The skin has an important job of protecting the body and acts as the body's first line of defense against infection, temperature change, and other challenges to homeostasis.
(2025). 9780805359107, Pearson Benjamin Cummings. .

Its main functions include:

  • Protect the body's internal living tissues and organs
  • Protect against invasion by foreign organisms, including organisms
  • Protect the body from
  • Protect the body against in , maintain
  • Help waste materials through
  • Act as a receptor for touch, pressure, pain, heat, and cold (see Somatosensory system)
  • Protect the body against by secreting melanin
  • Generate through exposure to
  • Store , , glucose, vitamin D
  • Maintenance of the body form
  • Formation of new cells from stratum germinativum to repair minor injuries
  • Protect from UV rays.
  • Regulates body temperature
  • It distinguishes, separates, and protects the organism from its surroundings.

Small-bodied invertebrates of aquatic or continually moist habitats respire using the outer layer (integument). This gas exchange system, where gases simply diffuse into and out of the interstitial fluid, is called integumentary exchange.


Clinical significance
Possible diseases and injuries to the human integumentary system include:


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