Some programming languages are case-sensitive for their identifiers (C, C++, Java, C#, Verilog,
A text search operation could be case-sensitive or case-insensitive, depending on the system, application, or context. The user can in many cases specify whether a search is sensitive to case, e.g. in most text editors, word processors, and Web browsers. A case-insensitive search is more comprehensive, finding "Language" (at the beginning of a sentence), "language", and "LANGUAGE" (in a title in capitals); a case-sensitive search will find the computer language "BASIC" but exclude most of the many unwanted instances of the word. For example, the Google Search engine is basically case-insensitive, with no option for case-sensitive search. In Oracle database SQL most operations and searches are case-sensitive by default, while in most other DBMS's SQL searches are case-insensitive by default.
Case-insensitive operations are sometimes said to fold case, from the idea of folding the character code table so that upper- and lower-case letters coincide.
In filesystems in Unix-like systems, filenames are usually case-sensitive (there can be separate readme.txt and Readme.txt files in the same directory). macOS is somewhat unusual in that, by default, it uses HFS Plus in a case-insensitive (so that there cannot be a readme.txt and a Readme.txt in the same directory) but case-preserving mode (so that a file created as readme.txt is shown as readme.txt and a file created as Readme.txt is shown as Readme.txt) by default. This causes some issues for developers and power users, because most other environments are case sensitive, but many Mac Installers fail on case sensitive file systems.
The older Microsoft Windows filesystems VFAT and FAT32 are not case-sensitive, but are case-preserving. The earlier FAT12 filesystem was case-insensitive and not case-preserving, so that a file whose name is entered as readme.txt or ReadMe.txt is saved as README.TXT. Later Windows file systems such as NTFS are internally case-sensitive, and a readme.txt and a Readme.txt can coexist in the same directory. However, for practical purposes filenames behave as case-insensitive as far as users and most software are concerned.