Butyrophenone is an organic compound with the formula C6H5C(O)C3H7. It is a colorless liquid.
The butyrophenone structure—a ketone flanked by a phenyl ring and a butyl group—forms the basis for many other chemicals containing various . Some of these butyrophenones are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.
Examples of butyrophenone-derived pharmaceuticals include:
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Benperidol‡
[‡ denotes drugs that are no longer (or were never to begin with) marketed in the United States. Some antipsychotics are not firmly placed in either first-generation or second-generation classes.] (200 times more potent than chlorpromazine)
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Bromperidol†
[† indicates drugs that are no longer (or were never) marketed in English-speaking countries.]
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Droperidol‡,
Antiemetic for postoperative nausea and vomiting
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Haloperidol, the most widely used classical antipsychotic drug in this class
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Lumateperone, an atypical antipsychotic used for schizophrenia and bipolar depression
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Moperone ( discontinued)†
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Pipamperone ( discontinued)†
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Timiperone†
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Lenperone
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Melperone