The House of Gattilusio was a powerful Genoese family who controlled a number of possessions in the northern Aegean Sea from 1355 until the mid 15th century. Anthony Luttrell has pointed out that this family had developed close connections to the Byzantine Empire ruling house of the Palaiologos—"four successive generations of Gattilusio married into the Palaiologos family, two to emperors' daughters, one to an emperor, and one to a despot who later became an emperor"—which could explain their repeated involvement in Byzantine affairs.Anthony Luttrell, "John V's Daughters: A Palaiologan Puzzle", Dumbarton Oaks Papers, 40 (1986), p. 112 The Gattilusi were Lords of Lesbos (present-day in Greece) from 1355 to 1462 and Lords of Enez (present-day in Turkey) from 1376 to 1456.
After the Fall of Constantinople in 1453, the Gattilusi briefly retained control of their possessions under Ottoman Empire suzerainty, but were forced out within a few years. In 1456, the Ottomans appointed a native Greek historian, Michael Critobulus, as governor of Imbros, and likewise removed the Gattilusi from power in the remainder of their possessions, with the exception of Lesbos, which they were permitted to retain in return for an annual payment of 4,000 gold pieces. The lord of Lesbos, Domenico Gattilusio, was strangled and briefly succeeded by his brother Niccolò, before an Ottoman fleet captured the island in September 1462, sending Niccolò as prisoner to Istanbul (where he was later executed) and putting an end to the family's power.Setton, vol. II, p. 238
Archaeological excavations in the castle of Mytilene since 1984 by the University of British Columbia under the direction of Caroline and Hector Williams have uncovered the burial chapel of the Gattilusi and a few graves that probably belonged to dependents of the family. The building was converted into a mosque after the Ottoman capture of Mytilene in 1462; an earthquake in February 1867 destroyed it. The Canadian excavations have also added a considerable number of Gattilusi coins to the known corpus, now published by Dr. Robert Weir
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