Ubenimex

 ( Alpha-amino Acids ) 

Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an enzyme inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A₄ hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D₄ hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia and lymphedema. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, , and various other and compounds.

• Amastatin
• Pepstatin

• The MEROPS online database for peptidases and their inhibitors: Bestatin