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Camptothecins in Cancer Therapy

ISBN 9781592598663
REGISTERED: 10/07/17
UPDATED: 08/18/18

Blood 98:3575–3583. Beran M, Shen Y, Kantarjian H, et al. 2001 High-dose chemotherapy in high-risk myelodysplastic syndrome: covariate-adjusted comparison of five regimens. Cancer 92:1999–2015. Miller CB, O'Reilly S, Sartorius S, et al.

  • ISBN bar code 9781592598663 ξ1 registered September 18 2015
  • Product category is Book

This volume presents a critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.

    ^ (2007). Camptothecins in Cancer Therapy (revised Nov 2015)

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