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The role of the Xenopus TACC protein maskin at the centrosome
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EAN 2940011718335
REGISTERED: 04/13/18
UPDATED: 03/31/20
The role of the Xenopus TACC protein maskin at the centrosome.
Cell polarity, adhesion, vesicular transport and mitotic spindle assembly are microtubule based processes made possible by the centrosome, a non-membranous organelle that nucleates, anchors, and stabilizes microtubules. Despite over 100 years of research on the centrosome, little is known about the molecular details of how the centrosome functions. The transforming acidic coiled-coil (TACC) family of proteins is implicated in centrosomal function. TACC proteins are characterized by ∼200


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  • EAN bar code 2940011718335 ξ1 registered March 16 2016
  • Product category is The-role-of-the-Xenopus-TACC-protein-maskin-at-the-centrosome Alison-J-Albee Electronic

Cell polarity, adhesion, vesicular transport and mitotic spindle assembly are microtubule based processes made possible by the centrosome, a non-membranous organelle that nucleates, anchors, and stabilizes microtubules. Despite over 100 years of research on the centrosome, little is known about the molecular details of how the centrosome functions. The transforming acidic coiled-coil (TACC) family of proteins is implicated in centrosomal function. TACC proteins are characterized by ∼200 amino acids coiled-coil at their C-terminus (TACC domain) with little homology outside of this domain. Depletion of TACC proteins from yeast, worms, flies and mice leads to embryonic lethality and disrupted microtubule based processes although the precise details of TACC protein function is lacking. My thesis research has focused on characterizing the Xenopus TACC protein maskin. Maskin localizes to the centrosome and is required to anchor MTs. The conserved portion of maskin, the TACC domain, is sufficient to rescue aster assembly defects induced by depletion of maskin from Xenopus egg extracts. The TACC domain is regulated the TACCless domain (non-conserved portion) and phosphorylation by the mitotic kinase Aurora A induces a conformational change liberating the TACC domain from inhibition. Additionally, maskin interacts with the major MT stabilizing factor in Xenopus egg extracts, XMAP215s and regulates the ability of XMAP215 to bind to MT minus ends. My thesis research highlight the critical function maskin plays at the centrosome.


References
    ^ The role of the Xenopus TACC protein maskin at the centrosome. (revised Mar 2020)

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