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Characterization of human neutralizing antibodies against severe acute respiratory syndrome coronavirus.

Severe acute respiratory syndrome coronavirus (SARS-CoV) is a newly emerged pathogen that causes respiratory distress in infected individuals with an overall mortality rate of approximately 10 percent. The spike (S) protein of SARS-CoV facilitates entry into susceptible cells via the cellular receptor ACE2. The S protein is divided into two functional domains; S1 mediates receptor binding and S2 mediates fusion of viral and host cell membranes. SARS-CoV S protein is the main antigenic target of

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