The Skin Rejuvenation Lotion lll makes skin become noticeable softer, smoother, and more radiant with use and you want to use it alternately with the Forte ll to help your skin accommodate to its high potency. It is for individuals who have used a high-level glycolic-based product for 4 to 6 months or been advised to use Skin Rejuvenation Lotion lll by physician.